Seismic anisotropy of mid crustal orogenic nappes and their bounding structures: An example from the Middle Allochthon (Seve Nappe) of the Central Scandinavian Caledonides

We report compositional, microstructural and seismic properties from 24 samples collected from the Middle Allochthon (Seve Nappe) of the central Scandinavian Caledonides, and its bounding shear zones. The samples stem both from field outcrops and the continental drilling project COSC-1 and include quartzofeldspathic gneisses, hornblende gneisses, amphibolites, marbles, calc-silicates, quartzites and mica schists, of medium to high-strain. Seismic velocities and anisotropy of P (AVp) and S (AVs) waves of these samples were calculated using microstructural and crystal preferred orientation data obtained from Electron Backscatter Diffraction analysis (EBSD). Mica-schist exhibits the highest anisotropy (AVP ~ 31%; max AVs ~34%), followed by hornblende-dominated rocks (AVp ~5–13%; max AVs 5–10%) and quartzites (AVp ~6.5–10.5%; max AVs ~7.5–12%). Lowest anisotropy is found in calc-silicate rocks (AVp ~4%; max AVs 3–4%), where the symmetry of anisotropy is more complex due to the contribution to anisotropy from several phases. Anisotropy is attributed to: 1) modal mineral composition, in particular mica and amphibole content, 2) CPO intensity, 3) crystallization of anisotropic minerals from fluids circulating in the shear zone (calc-silicates and amphibolites), and to a lesser extent 4) compositional banding of minerals with contrasting elastic properties and density. Our results link observed anisotropy to the rock composition and strain in a representative section across the Central Scandinavian Caledonides and indicate that the entire Seve Nappe is seismically anisotropic. Strain has partitioned on the nappe scale, and likely on the microstructural scale. High- strain shear zones that develop at boundaries of the allochthon and internally within the allochthon show higher anisotropy than a more moderately strained interior of the nappe. The Seve Nappe may be considered as a template for deforming, ductile and flowing middle crust, which is in line with general observations of seismic anisotropy in mid-crustal settings

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146621/1/cea13318.pd

Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II

In this article, we describe developments in the field of clinical allergy as described by Clinical and Experimental Allergy in 2018; epidemiology, asthma and rhinitis, clinical allergy and allergens are all covered.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153257/1/cea13535.pd

Core-log-seismic integration in metamorphic rocks and its implication for the regional geology: A case study for the ICDP drilling project COSC-1, Sweden

Continental collision causes deformation in the crust along shear zones. However, the physical and chemical conditions at which these zones operate and the deformation processes that enable up to hundreds of km of tectonic transport are still unclear because of the depth at which they occur and the challenges in imaging them. Ancient exhumed collision zones allow us to investigate these processes much better, for example at the COSC‐1 borehole in the central Scandinavian Caledonides. This study combines data from the COSC‐1 borehole with different seismic measurements to provide constraints on the spatial lithological and textural configuration of the Seve Nappe Complex. This is one of the few studies that shows that core‐log‐seismic integration in metamorphic rocks allows to identify the spatial distribution of major lithological units. Especially gamma ray logs in combination with density data are powerful tools to distinguish between mafic and felsic lithologies in log‐core correlation. Our results indicate that reflections along the borehole are primarily caused by compositional rather than textural changes. Reflections in the Seve Nappe Complex are not as distinct as in greater depths but continuous and several of them can be linked to magmatic intrusions, which have been metamorphically overprinted. Their setting indicates that the Seve Nappe Complex consists of the remnants of a volcanic continental margin. Our results suggest that ductile‐deformed middle crustal reflectivity is primarily a function of pre‐orogenic lithological variations which has to be considered when deciphering mountain building processes

Familial liability for eating disorders and suicide attempts : evidence from a population registry in Sweden

Importance: Suicide attempts are common in individuals with eating disorders. More precise understanding of the mechanisms underlying their co-occurrence is needed. Objective: To examine the association between eating disorders and suicide attempts and whether familial risk factors contribute to the association. Design: A cohort design following a Swedish birth cohort 1979-2001 from age 6 until 31/12/2009. Setting: Information was acquired from Swedish national registers. Participants: Individuals born 1979-2001 and living in Sweden before age 6 (N= 2,268,786) were eligible for the study. Each individual was linked to his/her biological full-siblings, maternal half-siblings, paternal half-siblings, full-cousins, and half-cousins. Eating disorders were captured by three variables: any eating disorder, anorexia nervosa (AN), and bulimia nervosa (BN), identified by any lifetime diagnoses recorded in the registers. Suicide attempts were defined as any suicide attempts, including death by suicide, recorded in the registers. We examined the association between eating disorders and death by suicide separately, but were underpowered to explore familial liability for this association. Results: Individuals with any eating disorder had increased risk of suicide attempts (OR=5.28, 95%CI [5.04, 5.54]) and death by suicide (OR=5.39, 95%CI [4.00, 7.25]). The risks attenuated but remained significant after adjusting for comorbid major depressive disorder, anxiety disorders, and substance use disorder. Similar results were found for AN and BN, except that adjusted OR of death by suicide in BN became insignificant, possibly due to insufficient power. Individuals (index) who had a full-sibling with any eating disorder had increased risk of suicide attempts (OR=1.41, 95%CI [1.29, 1.53]). The risk attenuated for any eating disorder in more distant relatives (maternal half-siblings, OR=1.10, 95%CI [0.90, 1.34]; paternal half-siblings, OR=1.21, 95%CI [0.98, 1.49]; full-cousins, OR=1.11, 95%CI [1.06, 1.18]; half-cousins, OR=0.90, 95%CI [0.78, 1.03]). This familial pattern remained stable after adjusting for the index individuals’ eating disorders. Similar patterns were found for AN and BN. Conclusions and Relevance: Our results suggest increased risk of suicide attempts in individuals with lifetime eating disorders and their relatives. The pattern of familial co-aggregation suggests familial liability for the association between eating disorders and suicide. Psychiatric comorbidities partially explain this association, suggesting particularly high-risk presentations.China Scholarship CouncilAmerican Foundation for Suicide PreventionSwedish Initiative for Research on Microdata in the Social and Medical Sciences framework, 340-2013-5867Swedish Research Council, 538-2013Global Foundation for Eating DisordersSwedish Research Council, 538-2013-8864Manuscrip

Study of in-medium ω\omega meson properties in Ap, pA and AA collisions

We propose to investigate the in-medium properties of vector $\omega$ mesons at the normal nuclear density in Ap(pA) collisions and at higher density in AA collisions at the ITEP accelerator facility TWAC. Using of the inverse Ap kinematics will permit us to study the $\omega$ meson production in a wide momentum interval included the not yet explored range of small meson momenta relative to the projectile nuclei where the mass modification effect in nuclear matter is expected to be the strongest. Momentum dependence of the in-medium $\omega$ meson width will be studied in the traditional pA kinematics. We intend to use the electromagnetic calorimeter for reconstruction of the $\omega$ meson invariant mass by detecting photons from the $\omega \to \pi^{0}\gamma \to 3\gamma$ decay. The model calculations and simulations with RQMD generator show feasibility of the proposed experiment. Available now intensity of the ion beams provides a possibility to collect large statistics and make decisive conclusion about the $\omega$ meson properties at density of normal nuclei. At the second stage of the investigation the $\omega$ meson properties will be studied in AA collisions at higher density. Interpretation of these measurements will be based on the results obtained in Ap(pA) interactions. Further investigation of the in-medium properties of light unflavored and charmed mesons can be performed at ITEP and at GSI(FAIR) where higher ion energies will be accessible in near future.Comment: 26 pages, 10 figures, 2 table

A Multi-Phase Transport model for nuclear collisions at RHIC

To study heavy ion collisions at energies available from the Relativistic Heavy Ion Collider, we have developed a multi-phase transport model that includes both initial partonic and final hadronic interactions. Specifically, the parton cascade model ZPC, which uses as input the parton distribution from the HIJING model, is extended to include the quark-gluon to hadronic matter transition and also final-state hadronic interactions based on the ART model. Predictions of the model for central Au on Au collisions at RHIC are reported.Comment: 7 pages, 4 figure

Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis

BackgroundImatinib, a tyrosine kinase inhibitor, has been shown to restore bloodâ brain barrier integrity and reduce infarct size, haemorrhagic transformation and cerebral oedema in stroke models treated with tissue plasminogen activator. We evaluated the safety of imatinib, based on clinical and neuroradiological data, and its potential influence on neurological and functional outcomes.MethodsA phase II randomized trial was performed in patients with acute ischaemic stroke treated with intravenous thrombolysis. A total of 60 patients were randomly assigned to four groups [3 (active): 1 (control)]; the active treatment groups received oral imatinib for 6 days at three dose levels (400, 600 and 800 mg). Primary outcome was any adverse event; secondary outcomes were haemorrhagic transformation, cerebral oedema, neurological severity on the National Institutes of Health Stroke Scale (NIHSS) at 7 days and at 3 months and functional outcomes on the modified Rankin scale (mRS).ResultsFour serious adverse events were reported, which resulted in three deaths (one in the control group and two in the 400â mg dose group; one patient in the latter group did not receive active treatment and the other received two doses). Nonserious adverse events were mostly mild, resulting in full recovery. Imatinib ameliorated neurological outcomes with an improvement of 0.6 NIHSS points per 100 mg imatinib (P = 0.02). For the 800â mg group, the mean unadjusted and adjusted NIHSS improvements were 4 (P = 0.037) and 5 points (P = 0.012), respectively, versus controls. Functional independence (mRS 0â 2) increased by 18% versus controls (61 vs. 79; P = 0.296).ConclusionThis phase II study showed that imatinib is safe and tolerable and may reduce neurological disability in patients treated with intravenous thrombolysis after ischaemic stroke. A confirmatory randomized trial is currently underway.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136298/1/joim12576_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136298/2/joim12576.pd